XPL, the University of Pennsylvania X-ray Physics Laboratory, is the research arm of the Physics Section - the oldest research section in the Department of Radiology. The Physic Section traces its origins to the pioneering work of Arthur Goodspeed, PhD, who acquired the first radiograph in Philadelphia on February 4, 1896. The XPL is currently lead by Dr. Andrew Maidment.

Today, the central focus of the XPL is the development of advanced methods for breast cancer imaging, including digital breast tomosynthesis (DBT) and functional breast imaging. Research efforts include the modeling and development of novel imaging systems, methods for characterizing image system performance and observer performance, and the development of novel image-based biomarkers for breast cancer risk assessment and prognosis. Significant effort has been expended in recent years on the development of contrast-enhanced digital breast tomosynthesis. This pioneering work is predicated upon the desire to combine morphologic and functional information to improve breast cancer diagnosis.

The laboratory, located in the John Morgan Building, is well equipped to perform fundamental x-ray system development, radiation dosimetry, phantom development, radiographic clinical trial support, and psychophysical observer studies.

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